PET Facilities & Equipment
All PET facilities and equipment are located on the first floor of the McDermott Clinical Sciences Building.
The PET Division has three sections:
Human PET Section
The Human PET Section occupies one, three-room suite (McDermott 1.310-1.314) on the first-floor of the McDermott Clinical Science Building. This suite consists of two scanner bays and an operator control room.
CTI/Siemens EXACT HR+
A 63-slice, high-sensitivity, high-resolution (4.1mm in 3D mode) whole body scanner capable of 2D and 3D data acquisition. This scanner has 18,432 BGO detectors and has an axial field of view of 15.5 cm. The sensitivity of this scanner at the center of field of view is 5.24 cps/kBq in 2D and 36.57 cps/Bq in 3D mode.
GE/Scanditronix 4096
A high-resolution (5.5mm), 15-slice, high-peak-count-rate camera. This device is no longer used for human imaging, but is used for development.
Metabolic Bed at Research Imaging Institute (RII)
Through ongoing collaborations with Dr. DeFronzo, completely equipped metabolic unit has been established at the RII to allows investigators to carry out euglycemic insulin/hyperglycemic clamps studies in combination with PET/18F-fluoro deoxy glucose and MRS/MRI.
Animal PET Section
The Animal PET Section occupies two, one-room suites (McDermott 1.510-, 1.926) on the first-floor of the McDermott Clinical Science Building. Each suite includes animal preparation space, dose-calibration equipment and an animal PET system. Equipment includes:
Siemens Focus 220 Primate microPET
168 LSO detector blocks and 24,193 crystal elements. Bore is 26 cm in diameter; Axial field of view, 8 cm. Reconstructed volume resolution- <2.5mm3. System is fully portable and can be tilt up to a 45o angle for optimal placement of large animals. Bore size is sufficiently large to accommodate a human head.
Concorde Rodent microPET
This scanner has 96 LSO detector blocks and 6,144 crystal elements. Bore is 10 cm in diameter; Axial field of view, 10 cm. Reconstructed volume resolution- <7.0mm3. System is fully portable.
PET – Radiochemistry
Eclipse HP cyclotron (Siemens)
Siemens Eclipse HP cyclotron, an 11 MeV negative ion single particle accelerator, produces Curie levels of positron emitting radioisotopes — 18F, 11C, 13N and 15O. Its self-shielded, automated design offers fast, easy, and efficient production of PET radioisotopes. The four position automated target carousel can be installed on either of two beamlines.
Scanditronix Model MC17F Cyclotron
A dual particle (proton and deuteron), fixed energy (17.2 MeV protons and 8.6 MeV deuterons), isochronous accelerator. Five targets are available for production of 11C, 18F, 13N, and 15O. The accelerator is located in a concrete shielded vault adjacent to the radiochemistry laboratory and directly across the hallway from the PET scanner suite.
Radiochemistry Laboratory
A fully equipped laboratory for providing a variety of positron- emitting radiopharmaceuticals to the PET scanner. Currently 15O-labeled water, 13N-labeled ammonia, 18F-labeled fluorodeoxyglucose, and 11C-labeled acetate are available for routine use. Synthesis systems include on-line production units, a laboratory robotics system, and a dedicated systems for production of 18F-labeled fluorodeoxyglucose, L-3,4-Dihydroxy-6- [18F]Fluorophenylalanine (18F−L−DOPA) and 18F− Fluormisonidazole (18F−FMISO). The laboratory also hosts an array of equipment including gas chromatography and high performance liquid chromatography systems to support the radiochemistry activities. This radiochemistry lab will also be capable of providing a variety of positron-emitting radiopharmaceuticals to the PET scanner including receptor ligands.
Quality Control Laboratory
A fully equipped laboratory located adjacent to the radiochemistry laboratory is capable of providing in-house radiopharmaceuticals and quality control procedures for all of the PET radiopharmaceuticals produced.
This quality control lab will also be capable of providing in-house radiopharmaceuticals and quality control procedures for all of the PET radiopharmaceuticals produced.