Cover Image HBM v38-10: Locked-in Children
Mariam Ishaque, Janessa H. Manning, Mary D. Woolsey, Crystal G. Franklin, Elizabeth W. Tullis, Christian F. Beckmann, Peter T. Fox
For details, see Ishaque, et al.
Abstract
Children resuscitated after near-fatal drowning often incur anoxic brain injury (ABI). Locked-in syndrome — a condition defined by the co-occurrence of quadriplegia and aphonia — is a previously unreported consequence of pediatric ABI. In this issue, Ishaque and colleagues report ICA analysis of resting-state fMRI (rs-fMRI) and network-based quantitative behavioral assessments in 10 children with drowning-induced ABI, each of whom exhibit some form of lockedin syndrome. On a per-subject basis, rs-fMRI network preservation closely paralleled behavioral results (r = 0.74), suggesting that rs-fMRI has the potential to assess cognitive status when communication is compromised.